CJC-1295 NO DAC

Growth Hormone-Releasing Peptide Therapy — Patient Information Sheet

What Is CJC-1295 NO DAC?

CJC-1295 NO DAC — also known as Modified GRF 1-29 or Mod GRF — is a synthetic analog of growth hormone-releasing hormone (GHRH), the natural signal your hypothalamus sends to the pituitary gland to trigger growth hormone (GH) production. Unlike its longer-acting counterpart, CJC-1295 WITH DAC, the “NO DAC” version does not contain a Drug Affinity Complex, giving it a short half-life of roughly 30 minutes. This allows it to create a single, sharp GH pulse that closely mimics the body’s own natural rhythm, rather than producing a sustained, non-pulsatile elevation.

How It Works

Receptor activation — binds directly to GHRH receptors on the anterior pituitary gland, stimulating the synthesis and release of growth hormone.
Pulsatile release — because it clears the body quickly, it produces a natural pulse of GH rather than an artificial, sustained spike — helping preserve the body’s own feedback mechanisms.
Downstream effect — the resulting GH release stimulates the liver to produce insulin-like growth factor 1 (IGF-1), a key mediator of tissue repair, fat metabolism, and lean mass support.
Common pairing — CJC-1295 NO DAC is frequently paired with a ghrelin-receptor secretagogue such as Ipamorelin, since the two peptides act on different pituitary pathways and produce a more robust, synergistic GH pulse.

Potential Benefits

Body composition — supports lean muscle development and may aid post-exercise recovery.
Fat metabolism — may promote mobilization of stored fat as an energy source, supporting weight management goals.
Sleep quality — higher-quality GH pulses are strongly tied to deep sleep, and patients often report improved sleep quality.
Tissue repair — IGF-1 support may contribute to improved skin elasticity, connective tissue integrity, and injury recovery.
Healthy aging support — GH and IGF-1 naturally decline with age; restoring more youthful pulsatile signaling is a primary reason patients pursue this therapy.
Physiologic approach — stimulates the body’s own GH production rather than introducing exogenous HGH, preserving natural feedback regulation.

Dosing Overview

Dosing is individualized by your Colorado Slim physician based on your health history, lab work, and treatment goals. The ranges below reflect typical protocols used in medically supervised GH-optimization therapy and are provided for educational purposes only — they are not a self-administration guide.

Parameter	Typical Range	Notes
Starting dose	100 mcg per injection (10 units)	Used to assess tolerance before escalating
Maintenance dose	100–300 mcg per injection (10-30 units)	1–3 times daily, per physician direction
Route	Subcutaneous injection	Site rotation recommended to reduce irritation
Timing	Fasted; morning and/or pre-bedtime	Elevated blood glucose or insulin blunts the GH response, so injections are typically given on an empty stomach
Monitoring	Baseline and follow-up IGF-1 labs	Typically reassessed 6–8 weeks after initiation

Important Safety Information

CJC-1295 NO DAC is not FDA-approved as a prescription drug; it should only be used under the direct supervision of a licensed prescriber, such as at Colorado Slim.
Never adjust your dose, frequency, or peptide combination without first speaking to your prescribing physician.
Common, generally mild effects can include injection-site redness, flushing, headache, or transient water retention. Report any side effects to your care team promptly.
This therapy is not appropriate for everyone, including patients with certain cancers, uncontrolled diabetes, or during pregnancy or breastfeeding. A full medical history review is required before starting treatment.

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